Immunotherapy with myeloid cells for tolerance induction
نویسندگان
چکیده
منابع مشابه
Modulation of Dendritic Cells for Tolerance Induction*
Dendritic cells (DC) are uniquely well-equipped antigen (Ag) presenting cells that initiate and regulate immune responses. DC play a dualistic role in the regulation of immune responses. They initiate adaptive immunity by the activating naive lymphocytes and are powerful stimulators of natural killer cells – the crucial cellular instigators of the innate immune system. Furthermore, DC induce ce...
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Post-remission therapy of patients with acute myeloid leukemia (AML) is critical for the elimination of minimal residual disease (MRD) and a prerequisite for achieving cure. Cellular immunotherapy is a highly effective treatment option as demonstrated by the low relapse rate after allogeneic stem cell transplantation (SCT). However, many patients are not eligible for this treatment. Therapeutic...
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Epicutaneous immunotherapy is a developing technique, aiming at desensitizing patients with food allergy with less risks that oral ingestion or injection could generate. Several clinical trials have been performed and are currently running, in milk and peanut allergy, assessing the safety of the technique and its efficacy. Preclinical models indicate a major role in the mechanisms of desensitiz...
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Background & Objective. Ultrarush induction for specific venom immunotherapy has been shown to be reliable and efficacious in adults. In this study its safety and tolerance in children was evaluated. Methods. Retrospective analysis of 102 ultrarush desensitizations carried out between 1997 and 2005 in 94 children, aged 4 to 15 years. Diagnosis and selection for immunotherapy were according to r...
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Our goal has been to develop ways to tolerize the mature immune system to any defined antigen. In this report we show that peripheral (post-thymic) T cells of mice can become tolerant to a range of antigens (human and rat immunoglobulins, and bone marrow and skin grafts that differ at multiple minor transplantation antigens). In the case of human gamma globulin (HGG), this required that the ant...
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ژورنال
عنوان ژورنال: Current Opinion in Organ Transplantation
سال: 2010
ISSN: 1087-2418
DOI: 10.1097/mot.0b013e32833bcf5e